NCT05429320View on ClinicalTrials.gov

A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)

PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

June 15, 2022

Primary Completion Date

June 15, 2026

Study Completion Date

June 15, 2026

Conditions
Non-small Cell Lung CancerMetastatic Non Small Cell Lung CancerNsclcNSCLC Stage IVMinimal Residual DiseaseNon Small Cell Lung Cancer Metastatic
Interventions
PROCEDURE

Local ablative therapy

In part I, 33 patients with metastatic NSCLC with: a) NR-VAF but b) without radiographic progression of disease, will be treated with LAT. In Part II of the study, patients will be randomized to standard of care (continuation of systemic therapy) vs. LAT to all sites of disease

OTHER

Blood collection to assess for ctDNA

Participants will undergo ctDNA collection in conjunction with their standard of care therapy.

Trial Locations (9)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York

10604

RECRUITING

Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale

11725

RECRUITING

Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities), Commack

33143

RECRUITING

BAPTIST ALLIANCE - MCI (Data collection only), Miami

06102

RECRUITING

Hartford Healthcare ALLIANCE (Data collection only), Hartford

07920

RECRUITING

Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale

All Listed Sponsors
lead

Memorial Sloan Kettering Cancer Center

OTHER