Neoadjuvant Arterial Embolization Chemotherapy Combined PD-1 Inhibitor for Locally Advanced Rectal Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

83

Participants

Timeline

Start Date

November 29, 2022

Primary Completion Date

November 30, 2024

Study Completion Date

October 31, 2025

Conditions
Rectal Neoplasms
Interventions
PROCEDURE

Arterial chemoembolization

The blood supplying artery of the tumor is selected for drug injection with Oxaliplatin 85mg/m2 combined Raltitrexed 3mg/m2. After drug injection, gelatin sponge is used for embolization.

DRUG

Tislelizumab Injection

Tislelizumab Injection 200mg i.v. q3w, A total of 3 cycles are administered.

DRUG

XELOX

Capecitabine 1,000 mg/m2 bid, po, on days 1-14 Oxaliplatin: 130 mg/m2, i.v. day 1 Cycles are repeated on day 22. A total of 3 cycles are administered.

DIAGNOSTIC_TEST

Pelvic MRI

Pelvic MRI to evaluate efficacy

PROCEDURE

Laparoscopic radical resection of rectal cancer

Surgical treatment for patients who meet the surgical conditions

Trial Locations (1)

322000

RECRUITING

The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu

All Listed Sponsors
collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

lead

The Fourth Affiliated Hospital of Zhejiang University School of Medicine

OTHER