Effectiveness of Cannabinoids on Appetite in Scleroderma

PHASE3CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

November 9, 2022

Primary Completion Date

October 31, 2024

Study Completion Date

December 31, 2024

Conditions
Systemic SclerosisMalnutritionLoss of Appetite
Interventions
DRUG

CBD oil

The subjects will receive cannabis 2.7 mg THC 2.5 mg CBD twice daily (1 droplet twice daily; 0.73 mg THC and 0.81 mg CBD/drop, 1.46 mg THC and 1.62 CBD/day) for 1 week then titrate up to 2 droplets twice daily if tolerated (2.92 mg THC and 3.24 CBD per day) and continue the treatment until the end of the study.

DRUG

Placebo

The subjects will receive 1 droplet of placebo twice daily then titrate up to 2 droplets twice daily if tolerated and continue the treatment until the end of the study.

Trial Locations (2)

40002

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen

Scleroderma Clinic, Faculty of Medicine, Khon Kaen University, Khon Kaen

All Listed Sponsors
lead

Khon Kaen University

OTHER