Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

268

Participants

Timeline

Start Date

September 15, 2022

Primary Completion Date

July 31, 2025

Study Completion Date

August 31, 2025

Conditions
Pulmonary Sarcoidosis
Interventions
DRUG

Efzofitimod 3 mg/kg

EfzofitimodIV infusion every 4 weeks for a total of 12 doses

DRUG

Efzofitimod 5 mg/kg

EfzofitimodIV infusion every 4 weeks for a total of 12 doses

DRUG

Placebo

Placebo IV infusion every 4 weeks for a total of 12 doses

Trial Locations (91)

10941

aTyr Investigative Site, Middletown

12208

aTyr Investigative Site, Albany

19140

aTyr Investigative Site, Philadelphia

20060

aTyr Investigative Site, Washington D.C.

20123

aTyr Investigative Site, Milan

21224

aTyr Investigative Site, Baltimore

22042

aTyr Investigative Site, Falls Church

23298

aTyr Investigative Site, Richmond

27710

aTyr Investigative Site, Durham

27834

aTyr Investigative Site, Greenville

28006

aTyr Investigative Site, Madrid

28031

aTyr Investigative Site, Madrid

30308

aTyr Investigative Site, Atlanta

30625

aTyr Investigative Site, Hanover

31000

aTyr Investigative Site, Toulouse

32610

aTyr Investigative Site, Gainesville

33331

aTyr Investigative Site, Weston

33606

aTyr Investigative Site, Tampa

34149

aTyr Investigative Site, Trieste

34295

aTyr Investigative Site, Montpellier

35128

aTyr Investigative Site, Padua

35294

aTyr Investigative Site, Birmingham

37055

aTyr Investigative Site, Dickson

38700

aTyr Investigative Site, La Tronche

39008

aTyr Investigative Site, Santander

39216

aTyr Investigative Site, Jackson

40202

aTyr Investigative Site, Louisville

44195

aTyr Investigative Site, Cleveland

45122

aTyr Investigative Site, Essen

45219

aTyr Investigative Site, Cincinnati

46010

aTyr Investigative Site, Valencia

47121

aTyr Investigative Site, Forlì

48202

aTyr Investigative Site, Detroit

49301

aTyr Investigative Site, Ada

50134

aTyr Investigative Site, Florence

53100

aTyr Investigative Site, Siena

55455

aTyr Investigative Site, Minneapolis

55905

aTyr Investigative Site, Rochester

60611

aTyr Investigative Site, Chicago

60612

aTyr Investigative Site, Chicago

63110

aTyr Investigative Site, St Louis

69126

aTyr Investigative Site, Heidelberg

70115

aTyr Investigative Site, New Orleans

73104

aTyr Investigative Site, Oklahoma City

75015

aTyr Investigative Site, Paris

75246

aTyr Investigative Site, Dallas

75390

aTyr Investigative Site, Dallas

77030

aTyr Investigative Site, Houston

79106

aTyr Investigative Site, Freiburg im Breisgau

80131

aTyr Investigative Site, Napoli

80206

aTyr Investigative Site, Denver

84132

aTyr Investigative Site, Salt Lake City

85027

aTyr Investigative Site, Phoenix

90033

aTyr Investigative Site, Los Angeles

93000

aTyr Investigative Site, Bobigny

95124

aTyr Investigative Site, Catania

95817

aTyr Investigative Site, Sacramento

97220

aTyr Investigative Site, Portland

02114

aTyr Investigative Site, Boston

29425-0630

aTyr Investigative Site, Charleston

40220-005

aTyr Investigative Site, Salvador

90020-090

aTyr Investigative Site, Porto Alegre

09780-000

aTyr Investigative Site, São Bernardo do Campo

04039-901

aTyr Investigative Site, São Paulo

05403-900

aTyr Investigative Site, São Paulo

00168

aTyr Investigative Site, Rome

036-8563

Kyorin Investigative Site, Aomori

814-0180

Kyorin Investigative Site, Fukuoka

960-1295

Kyorin Investigative Site, Fukushima

060-0033

Kyorin Investigative Site, Hokkaido

060-8648

Kyorin Investigative Site, Hokkaido

653-0013

Kyorin Investigative Site, Hyōgo

236-0004

Kyorin Investigative Site, Kanagawa

236-0051

Kyorin Investigative Site, Kanagawa

860-8556

aTyr Investigative Site, Kumamoto

980-8574

Kyorin Investigative Site, Miyagi

700-8558

Kyorin Investigative Site, Okayama

591-8025

Kyorin Investigative Site, Osaka

693-8501

Kyorin Investigative Site, Shimane

431-3192

Kyorin Investigative Site, Shizuoka

150-8935

Kyorin Investigative Site, Tokyo

151-8528

Kyorin Investigative Site, Tokyo

3435CM

aTyr Investigative Site, Nieuwegein

08036

aTyr Investigative Site, Barcelona

08907

aTyr Investigative Site, Barcelona

B15 2TH

aTyr Investigative Site, Birmingham

CB233RE

aTyr Investigative Site, Cambridge

HU16 5JQ

aTyr Investigative Site, Cottingham

CV2 2DX

aTyr Investigative Site, Coventry

SE59RS

aTyr Investigative Site, London

SW3 6NP

aTyr Investigative Site, London

Sponsors
All Listed Sponsors
collaborator

Kyorin Pharmaceutical Co.,Ltd

INDUSTRY

lead

aTyr Pharma, Inc.

INDUSTRY

NCT05415137 - Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis | Biotech Hunter | Biotech Hunter