900
Participants
Start Date
February 1, 2020
Primary Completion Date
December 31, 2026
Study Completion Date
June 30, 2030
ADT
The ADT regimen will be determined by the investigators at separate centers. The dose and frequency of administration will be consistent with the prescribing information. Available drugs include triptorelin, goserelin, leuprolide, digareke ect.
Abiraterone Acetate
1000 mg (250 mg×4 tablets) once daily, orally
Prednisolone tablets
5 mg once daily, orally.
Enzalutamide
160 mg (40 mg× 4 tablets) once daily, orally.
Apalutamide
240 mg (60 mg×4 tablets) once daily, orally.
Darotamide
600 mg (300 mg × 2 tablets) twice daily, orally.
Rezvilutamide
240 mg (80 mg × 3 tablets) once daily orally
PARP inhibitor
The PARP inhibitors will be determined by the investigators at separate centers. The dosage and frequency of administration will be consistent with the prescribing information. Available drugs include olaparib, fluzoparib, pamiparib, talazoparib ect.
Robot-assisted radical prostatectomy
Robot-assisted radical prostatectomy was performed within 2 weeks after the end of the therapy.
RECRUITING
Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
OTHER