Niraparib In Recurrent IDH 1/2 Gliomas

EARLY_PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

May 18, 2023

Primary Completion Date

January 31, 2026

Study Completion Date

February 28, 2026

Conditions
Low-grade GliomaIDH2 Gene MutationRecurrent GliomaIDH1 MutationGlioma, Malignant
Interventions
DRUG

Niraparib

Oral, daily, dosage per protocol,4 Weeks

DRUG

Resection/Treatment with Niraparib

"The participants in both arms will resume/start on treatment with niraparib 2 -4 weeks after surgery.~Treatment can be held for an additional 28 days to allow for recovery from surgery, at the investigator's discretion. Participants will continue treatment for up to 12 total cycles of treatment or until tumor progression, unacceptable toxicity or withdrawal of consent."

Trial Locations (1)

02115

Massachusetts General Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

Massachusetts General Hospital

OTHER

NCT05406700 - Niraparib In Recurrent IDH 1/2 Gliomas | Biotech Hunter | Biotech Hunter