SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

531

Participants

Timeline

Start Date

June 23, 2022

Primary Completion Date

November 6, 2024

Study Completion Date

March 23, 2027

Conditions
Plasma Cell Myeloma Recurrent
Interventions
DRUG

Isatuximab IV

Pharmaceutical form: Concentrate solution for IV infusion; Route of administration: Intravenous

DRUG

Isatuximab SC

Pharmaceutical form: Solution for subcutaneous administration; Route of administration: Subcutaneous (SC)

DRUG

Dexamethasone

Pharmaceutical form: Tablet; Route of administration: Oral

DRUG

Pomalidomide

Pharmaceutical form: hard capsules; Route of administration: Oral

DRUG

Dexamethasone

Pharmaceutical form: As per local commercial product; Route of administration: Oral; Auxiliary Medicinal Product (AxMP) i.e., background treatment; ATC code: H02AB02

DRUG

Montelukast

Pharmaceutical form: As per local commercial product; Route of administration: Oral; AxMP i.e., background treatment; ATC code: R03DC03

DRUG

Paracetamol / Acetaminophen

Pharmaceutical form: As per local commercial product; Route of administration: Oral; AxMP i.e., background treatment; ATC code: N02BE01

DRUG

Diphenhydramine

Pharmaceutical form: As per local commercial product; Route of administration: As premedication- oral; for management of infusion reactions-IV (or oral equivalent); AxMP i.e., background treatment and rescue medication (in case of infusion reactions); ATC code: R06AA02

DRUG

Methylprednisolone

Pharmaceutical form: As per local commercial product; Route of administration: As premedication-IV; for management of infusion reactions- IV (or oral equivalent); AxMP i.e., background treatment and rescue medication (in case of infusion reactions); ATC code: H02AB04

Trial Locations (146)

704

Investigational Site Number : 1580005, Tainan City

1083

Investigational Site Number : 3480002, Budapest

1097

Investigational Site Number : 3480004, Budapest

1199

Investigational Site Number : 0320002, Ciudad Autonoma Buenos Aires

1280

Investigational Site Number : 0320007, CABA

1417

Investigational Site Number : 0320003, CABA

1430

Investigational Site Number : 0320001, CABA

1900

Investigational Site Number : 0320006, La Plata

2170

Investigational Site Number : 0360007, Liverpool

2298

Investigational Site Number : 0360004, Waratah

2500

Investigational Site Number : 0360003, Wollongong

3004

Investigational Site Number : 0360006, Melbourne

3065

Investigational Site Number : 0360009, Fitzroy

3121

Investigational Site Number : 0360001, Richmond

5000

Investigational Site Number : 0360008, Adelaide

6026

Investigational Site Number : 5780002, Ålesund

7400

Investigational Site Number : 3480003, Kaposvár

7624

Investigational Site Number : 3480008, Pécs

8000

Investigational Site Number : 3480005, Székesfehérvár

9700

Investigational Site Number : 3480006, Szombathely

10002

Investigational Site Number : 1580002, Taipei

10676

Investigational Site Number : 3000002, Athens

11528

Investigational Site Number : 3000001, Athens

12206

New York Oncology Hematology, P.C.- Site Number : 8400017, Albany

12808

Investigational Site Number : 2030004, Prague

14186

Investigational Site Number : 7520003, Stockholm

18045

Spoknwrd Clinical Trials Inc. Site Number : 8400023, Easton

20817

Centre for Cancer and Blood Disorders- Site Number : 8400026, Bethesda

22763

Investigational Site Number : 2760001, Hamburg

23538

Investigational Site Number : 2760006, Lübeck

24000

Investigational Site Number : 2500008, Périgueux

25123

Investigational Site Number : 3800005, Brescia

26500

Investigational Site Number : 3000003, Pátrai

27100

Investigational Site Number : 3800003, Pavia

27103

Novant Health Forsyth Medical Center Site Number : 8400114, Winston-Salem

28034

Investigational Site Number : 7240005, Madrid

28046

Investigational Site Number : 7240007, Madrid

28207

Novant Health- Site Number : 8400014, Charlotte

29303

Gibbs Cancer Center-Spartanburg Medical Center- Site Number : 8400002, Spartanburg

30120

Investigational Site Number : 7240006, Murcia

31008

Investigational Site Number : 7240001, Pamplona

31059

Investigational Site Number : 2500003, Toulouse

32224

Mayo Clinic- Site Number : 8400008, Jacksonville

33322

BRCR Medical Center Inc Site Number : 8400030, Plantation

34093

Investigational Site Number : 7920003, Istanbul

34098

Investigational Site Number : 7920005, Istanbul

34214

Investigational Site Number : 7920008, Istanbul

34381

Investigational Site Number : 7920001, Istanbul

35100

Investigational Site Number : 7920004, Bornova

37007

Investigational Site Number : 7240002, Salamanca

37044

Investigational Site Number : 2500007, Tours

39008

Investigational Site Number : 7240003, Santander

39401

Hattiesburg Clinic Site Number : 8400006, Hattiesburg

40138

Investigational Site Number : 3800002, Bologna

42055

Investigational Site Number : 2500009, Saint-Etienne

44093

Investigational Site Number : 2500002, Nantes

44718

Gabrail Cancer Center Site Number : 8400027, Canton

45236

Oncology_Hematology Care Clinical Trials, LLC- Site Number : 8400016, Cincinnati

45500

Investigational Site Number : 3000005, Ioannina

47014

Investigational Site Number : 3800001, Meldola

50182

Investigational Site Number : 7520001, Borås

53188

UW Cancer Center at ProHealth Care Site Number : 8400001, Waukesha

57010

Investigational Site Number : 3000004, Thessaloniki

60126

Investigational Site Number : 3800004, Ancona

62500

Investigational Site Number : 2030005, Brno

69120

Investigational Site Number : 2760003, Heidelberg

70852

Investigational Site Number : 2030006, Ostrava - Poruba

75012

Investigational Site Number : 2500005, Paris

75246

Texas Oncology Baylor Sammons- Site Number : 8400022, Dallas

75390

University of Texas Southwestern- Site Number : 8400024, Dallas

77339

Lumi Research- Site Number : 8400029, Kingwood

77900

Investigational Site Number : 2030003, Olomouc

78240

Texas Oncology - San Antonio- Site Number : 8400020, San Antonio

80012

Rocky Mountain Cancer Centers, LLP- Site Number : 8400021, Aurora

80131

Investigational Site Number : 3800007, Napoli

83301

Investigational Site Number : 1580001, Kaohsiung City

84148

George E. Wahlen Salt Lake City VA Medical Center- Site Number : 8400011, Salt Lake City

86021

Investigational Site Number : 2500001, Poitiers

86314

Arizona Oncology Associates, PC - HAL- Site Number : 8400015, Prescott Valley

86442

Mohtaseb Cancer Center and Blood Disorders Site Number : 8400028, Bullhead City

89169

Comprehensive Cancer Centers of Nevada- Site Number : 8400019, Las Vegas

90127

Investigational Site Number : 3800008, Palermo

90419

Investigational Site Number : 2760007, Nuremberg

97401

Oncology Associates Of Oregon, P.C.- Site Number : 8400018, Eugene

100044

Investigational Site Number : 1560001, Beijing

100191

Investigational Site Number : 1560022, Beijing

110022

Investigational Site Number : 1560013, Shenyang

266000

Investigational Site Number : 1560011, Qingdao

300020

Investigational Site Number : 1560007, Tianjin

300032

Investigational Site Number : 1560009, Tianjin

300060

Investigational Site Number : 1560018, Tianjin

310003

Investigational Site Number : 1560002, Hangzhou

330006

Investigational Site Number : 1560020, Nanchang

410013

Investigational Site Number : 1560010, Changsha

430022

Investigational Site Number : 1560003, Wuhan

430030

Investigational Site Number : 1560008, Wuhan

450008

Investigational Site Number : 1560004, Zhengzhou

510060

Investigational Site Number : 1560006, Guangzhou

530000

Investigational Site Number : 1560019, Nanning

4800827

Investigational Site Number : 1520001, Temuco

7500921

Investigational Site Number : 1520003, Santiago

7580206

Investigational Site Number : 1520002, Santiago

7620157

Investigational Site Number : 1520006, Santiago

8380455

Investigational Site Number : 1520004, Santiago

07960

Atlantic Health System Site Number : 8400005, Morristown

C1180

Investigational Site Number : 0320008, CABA

C1425ASG

Investigational Site Number : 0320005, CABA

X5008HHW

Investigational Site Number : 0320010, Córdoba

1426ANZ

Investigational Site Number : 0320004, Buenos Aires

M5501

Investigational Site Number : 0320009, Mendoza

60115-281

NOHC - Nucleo de Oncologia e Hematologia do Ceara- Site Number : 0760006, Fortaleza

50070-460

OC ONCOCLINICAS MULTIHEMO ILHA DO LEITE Site Number : 0760007, Recife

24020-096

CHN - Complexo Hospitalar de Niteroi Site Number : 0760008, Niterói

90110-270

Hospital Mae de Deus Site Number : 0760003, Porto Alegre

04537-081

Clínica São Germano- Site Number : 0760001, São Paulo

22775-002

Instituto COI de Educacao e Pesquisa- Site Number : 0760004, Rio de Janeiro

M5G 2M9

Investigational Site Number : 1240001, Toronto

J4V 2H1

Investigational Site Number : 1240004, Greenfield Park

H1T 2M4

Investigational Site Number : 1240003, Montreal

Unknown

Investigational Site Number : 1520005, Viña del Mar

01307

Investigational Site Number : 2760005, Dresden

00168

Investigational Site Number : 3800006, Rome

467-8602

Investigational Site Number : 3920001, Nagoya

296-8602

Investigational Site Number : 3920007, Kamogawa-shi

311-3193

Investigational Site Number : 3920005, Higashiibaraki-gun

028-3695

Investigational Site Number : 3920010, Shiwa-gun

247-0072

Investigational Site Number : 3920012, Kamakura-shi

603-8151

Investigational Site Number : 3920003, Kyoto

981-1293

Investigational Site Number : 3920006, Natori-shi

701-1192

Investigational Site Number : 3920002, Okayama

530-8480

Investigational Site Number : 3920011, Osaka

411-8777

Investigational Site Number : 3920008, Sunto-gun

150-8935

Investigational Site Number : 3920004, Shibuya-ku

990-9585

Investigational Site Number : 3920009, Yamagata

0450

Investigational Site Number : 5780001, Oslo

30-688

Investigational Site Number : 6160005, Krakow

50-367

Investigational Site Number : 6160004, Wroclaw

20,081

Investigational Site Number : 6160001, Lublin

08916

Investigational Site Number : 7240004, Badalona

06010

Investigational Site Number : 7920007, Ankara

06200

Investigational Site Number : 7920009, Ankara

LE1 5WW

Investigational Site Number : 8260002, Leicester

W12 0HS

Investigational Site Number : 8260005, London

NR4 7UY

Investigational Site Number : 8260001, Norwich

B15 2GW

Investigational Site Number : 8260004, Birmingham

DE223NE

Investigational Site Number : 8260003, Derby

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Sanofi

INDUSTRY

NCT05405166 - SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM | Biotech Hunter | Biotech Hunter