AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip

PHASE1RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

March 13, 2023

Primary Completion Date

January 1, 2026

Study Completion Date

January 1, 2027

Conditions
Hip ArthroscopyArticular Cartilage DefectMicrofractures
Interventions
PROCEDURE

Autologous matrix-induced chondrogenesis (AMIC)

AMIC is a novel approach in which the microfracture technique has been enhanced by the use of a type I/III collagen matrix (Chondro-Gide®; Geistlich Pharma AG, Wolhusen, Switzerland). In this single-step procedure, the matrix is placed over the defect to stabilize the fragile blood clot that arises from microfracture and to provide infrastructure for repair tissue formation. Essentially, the matrix covers the defect and serves as a protective shield that contains the cells and minimizes the impact of shear forces when moving the hip on the delicate blood clot. At the same time, it functions as the roof of a biological chamber that forms over the defect. The biocompatible collagen material provides an environment for cell growth and is replaced by native tissue over time.

Trial Locations (1)

L8N3Z5

RECRUITING

McMaster University, Hamilton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Geistlich Pharma AG

INDUSTRY

lead

McMaster University

OTHER