Base Edited CAR7 T Cells to Treat T Cell Malignancies (TvT CAR7)

PHASE1UnknownINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

April 19, 2022

Primary Completion Date

April 1, 2024

Study Completion Date

February 28, 2025

Conditions
Relapsed/Refractory T-cell Acute Lymphoid Leukaemia
Interventions
BIOLOGICAL

Cryopreserved BE CAR7 T cells (BE752TBCCLCAR7PBL)

Single-dose intravenous infusion (weight-based dosing) of a banded dose of CAR7+ T cells/kg BECAR7 Total duration of treatment: 28 days Follow-up: 12 months

Trial Locations (1)

WC1N 1EH

RECRUITING

Ilyas Ali, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

UCL Great Ormond Street Institute of Child Health

OTHER

collaborator

Medical Research Council

OTHER_GOV

lead

Great Ormond Street Hospital for Children NHS Foundation Trust

OTHER