900
Participants
Start Date
July 4, 2022
Primary Completion Date
May 31, 2026
Study Completion Date
August 31, 2026
Point-of-Care Cepheid Xpert HIV-1
Post-partum HIV-positive women with pre-determined risk factors for vertical HIV transmission will be offered point-of-care HIV testing for their newborns for early infant HIV diagnosis.
DTG/ABC/3TC
Infants will be started on a combination of NVP/ZDV/3TC. A switch to DTG/ABC/3TC will occur for all infants at or after 4 weeks (28 days) post-delivery for those weighing ≥3kg. Dosing of all ART will be weight-based by the Botswana treatment guidelines.
Botswana Harvard HIV/AIDS Institute Partnership, Gaborone
Botswana Harvard AIDS Institute Partnership
OTHER
Ragon Institute of MGH, MIT and Harvard
OTHER
Botswana Ministry of Health
OTHER_GOV
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Harvard School of Public Health (HSPH)
OTHER