Pembrolizumab and Lenvatinib for Resectable Hepatocellular Carcinoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

September 30, 2022

Primary Completion Date

December 15, 2023

Study Completion Date

July 31, 2025

Conditions
Carcinoma, Hepatocellular
Interventions
DRUG

Pembrolizumab+Lenvatinib

"After enrollment, subjects receive pembrolizumab 200 mg via IV infusion on Day 1 of each 3-week cycle for 9 weeks: Lenvatinib 8 mg (body weight \<60 kg) or 12 mg (body weight ≥60 kg) orally once daily for 9 weeks.~Subjects conduct surgery 1 week after the last dose of Lenvatinib. 4 weeks after surgery, Pembrolizumab and Lenvatinib will restart as adjuvant treatment for up to 1 year."

Trial Locations (4)

200032

Zhongshan hospital, Shanghai

Unknown

Eastern Hepatobiliary Surgery Hospital, Shanghai

Ruijin Hospital, Shanghai

The first affiliated hospital, Yat-sen university, Guangzhou

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Shanghai Zhongshan Hospital

OTHER