NCT05388656View on ClinicalTrials.gov

Estrogen Variability and Irritability During the Menopause Transition

PHASE4CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 15, 2022

Primary Completion Date

December 17, 2024

Study Completion Date

January 17, 2025

Conditions
MenopauseIrritable Mood
Interventions
DRUG

Estradiol Patch, 0.1 mg/24 Hours Weekly Transdermal Film, Extended Release

0.1 mg/day transdermal patch administered for 3 weeks

DRUG

Placebo

Estradiol-matched placebo patch administered for 3 weeks

DRUG

Progesterone 200 mg

200 mg tablet administered by mouth once per day for 10 days after completion of the experimental phase of the study

Trial Locations (1)

27517

Carolina Crossing B, Suite 1, Chapel Hill

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

University of North Carolina, Chapel Hill

OTHER