NCT05384678View on ClinicalTrials.gov

Acute Dose-dependent Effects of DMT in Healthy Subjects

PHASE1CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

November 15, 2022

Primary Completion Date

March 8, 2024

Study Completion Date

March 13, 2024

Conditions
Healthy
Interventions
DRUG

N,N-Dimethyltryptamine (54 mg)

A dose rate of 0.6 mg/min will be administered

DRUG

N,N-Dimethyltryptamine (108 mg)

A dose rate of 1.2 mg/min will be administered

DRUG

N,N-Dimethyltryptamine (162 mg)

A dose rate of 1.8 mg/min will be administered

DRUG

N,N-Dimethyltryptamine (216 mg)

A dose rate of 2.4 mg/min will be administered

DRUG

Placebo

A Placebo (saline infusion) will be administered.

DRUG

N,N-Dimethyltryptamine (108 mg) + dose titration

A dose rate of 1.2 mg/min will be administered with subsequent patient-guided dose titration

Trial Locations (1)

4056

Universtity Hospital Basel, Basel

All Listed Sponsors
lead

University Hospital, Basel, Switzerland

OTHER