Axitinib and Nivolumab for the Treatment of Mucosal Melanoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

May 17, 2022

Primary Completion Date

May 31, 2026

Study Completion Date

May 31, 2026

Conditions
Mucosal Melanoma
Interventions
DRUG

Nivolumab and/or Ipilimumab

Combination of nivolumab 3mg/kg IV every 3 weeks with ipilimumab 1mg/kg or nivolumab 480mg IV every 4 weeks as monotherapy is considered standard of care for patients with unresectable locally advanced or metastatic mucosal melanoma.

RADIATION

Stereotactic Body Radiation Therapy (SBRT)

SBRT upon local or oligometastatic progression. The prescribed dose of SBRT will be 30 Gy in 5 fractions.

DRUG

axitinib

5mg twice daily

Trial Locations (2)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Memorial Sloan Kettering Cancer Center

OTHER

NCT05384496 - Axitinib and Nivolumab for the Treatment of Mucosal Melanoma | Biotech Hunter | Biotech Hunter