Clinical Characteristics, Natural Outcome and Treatment Optimization of Refractory

RecruitingOBSERVATIONAL
Enrollment

110

Participants

Timeline

Start Date

January 1, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Hepatitis B, ChronicVirus Diseases
Interventions
OTHER

original therapy

* Patients on ETV 0.5mg/ day or TDF 300mg/ day or TAF 25mg/ day continued the original regimen (ETV 1.0mg/ day or TDF 300mg/ day or TAF 25mg/ day), Oral treatment lasted 48 weeks ②Patients who received TDF 300mg/ day plus ETV 0.5mg/ day on initial treatment continued with the original regimen (TDF 300mg/ day plus ETV 0.5mg/ day) and oral therapy for 48 weeks ③Patients who received TAF 25mg/ day plus ETV 0.5mg/ day as initial treatment continued the original regimen (TAF 25mg/ day plus ETV 0.5mg/ day) for 48 weeks of oral therapy

OTHER

rescue therapy

TDF 300mg/ day +ETV 1.0mg/ day or TAF 25mg/ day +ETV 1.0mg/ day, oral treatment for 48 weeks.

Trial Locations (13)

Unknown

RECRUITING

Ankang Central Hospital, Ankang

RECRUITING

Hanzhong 3201 Hospital, Hanzhong

RECRUITING

Qianfhan Hospital, Jinan

RECRUITING

Weinan Central Hospital, Weinan

RECRUITING

Wuhan Union Hospital, Wuhan

RECRUITING

Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

RECRUITING

Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an

RECRUITING

Shaanxi Provincial People's Hospital, Xi'an

RECRUITING

Tang-Du Hospital, Xi'an

RECRUITING

Xi'an Central Hospital, Xi'an

RECRUITING

Xijing hospital of air force Medical University, Xi'an

RECRUITING

Yan'an University Affiliated Hospital, Yan’an

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

All Listed Sponsors
lead

First Affiliated Hospital Xi'an Jiaotong University

OTHER