Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction

3.0 mg/ml (titrated to 2.4 mg) subcutaneous once weekly for 12 months

Matched placebo with no active drug once weekly for 12 months

All participants will receive counselling on healthy lifestyle intervention including limiting consumption of salt, red meat, saturated or trans fats, sweets, and sugar-sweetened beverages, and how to restrict calorie intake (500 kcal/day deficit) in consultation with a trained study dietician. Regular physical activity \>150 minutes per week will be encouraged.