Zanubrutinib and Eltrombopag as Second-line Treatment in Adults With Primary Immune Thrombocytopenia

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

June 1, 2022

Primary Completion Date

June 1, 2025

Study Completion Date

December 30, 2025

Conditions
Immune Thrombocytopenia
Interventions
DRUG

Zanubrutinib

Zanubrutinib 80mg po qd 6 weeks

DRUG

Eltrombopag

eltrombopag 50 mg qd for up to 6 weeks. The eltrombopag dose could be increased from 50 mg to 75 mg after 3 weeks in patients whose platelet counts were less than 50 000 per μL. Treatment was discontinued in patients who attained a platelet count greater than 200 000 per μL.

Trial Locations (1)

100010

Peking University Insititute of Hematology, Peking University People's Hospital, Beijing

All Listed Sponsors
collaborator

Beijing Hospital

OTHER_GOV

collaborator

Navy General Hospital, Beijing

OTHER

collaborator

Beijing Aerospace General Hospital

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Beijing Tongren Hospital

OTHER

lead

Peking University People's Hospital

OTHER