Food Intake and Epigenetic Alteration in the Spermatozoa of Singletons and Twins

NACompletedINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

October 20, 2021

Primary Completion Date

July 1, 2022

Study Completion Date

July 1, 2022

Conditions
Fertility IssuesNutrition, HealthyEpigenetic DisorderOvernutrition
Interventions
DIETARY_SUPPLEMENT

Isocaloric Unprocessed Diet

Intervention consists of an unprocessed diet meeting the Nordic and Australian Dietary Guidelines for food groups and micronutrients, wherein participants will be supplied with food providing kilocalories (kcal) in accordance with their nutritional needs as calculated based on theSchofield equation based on their weight, activity multiplier, and age at baseline. Almost all food and beverage products provided during this treatment to fall into the category of unprocessed/minimally processed foods and processed culinary ingredients in accordance with the NOVA classification system.

DIETARY_SUPPLEMENT

Isocaloric Processed Diet

Intervention consists of a processed diet based on the dietary intake pattern resembling a processed western dietary intake pattern representative of the typical intake pattern of American men aged 19- 50, wherein participants will be supplied with food providing kcals in accordance with their nutritional needs as calculated based on the Schofield equation based on their height, weight, activity multiplier, and age at baseline. Almost all food and beverage products provided during this treatment to fall into the category of processed foods and ultra-processed foods in accordance with the NOVA classification system.

DIETARY_SUPPLEMENT

Excess Calorie Unprocessed Diet

Intervention consists of an unprocessed diet meeting the Nordic and Australian Dietary Guidelines for food groups and micronutrients, wherein participants will be supplied with food providing kilocalories (kcal) in accordance with their nutritional needs as calculated based on theSchofield equation based on their weight, activity multiplier, and age at baseline, plus an excess of 500 kcal per day. Almost all food and beverage products provided during this treatment to fall into the category of unprocessed/minimally processed foods and processed culinary ingredients in accordance with the NOVA classification system.

DIETARY_SUPPLEMENT

Excess Calorie Processed Diet

Intervention consists of a processed diet based on the dietary intake pattern resembling a processed western dietary intake pattern representative of the typical intake pattern of American men aged 19- 50, wherein participants will be supplied with food providing kcals in accordance with their nutritional needs as calculated based on the Schofield equation based on their height, weight, activity multiplier, and age at baseline, plus an excess of 500 kcal per day. Almost all food and beverage products provided during this treatment to fall into the category of processed foods and ultra-processed foods in accordance with the NOVA classification system.

Trial Locations (1)

2200

University of Copenhagen, Copenhagen

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Deakin University

OTHER

collaborator

Monash Health

OTHER

lead

University of Copenhagen

OTHER