Durable Effect of Imeglimin on the Glycemic Control in Patients With Type 2 Diabetes Mellitus

Imeglimin 1000 mg orally twice daily in the morning and evening (2000 mg daily).

Metformin 500 mg orally twice daily in the morning and evening (1000 mg daily). However, until 2 weeks after the start of treatment, 250 mg should be administered orally twice daily in the morning and evening. Thereafter, after 4, 8, or 12 weeks, the dose may be increased up to 750 mg twice daily (1500 mg daily) if the physician determines that the hypoglycemic effect is inadequate.

Vildagliptin 50 mg orally twice daily in the morning and evening (100 mg daily).