A Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Glofitamab in Combination With Rituximab Plus Ifosfamide, Carboplatin Etoposide Phosphate in Participants With Relapsed/Refractory Transplant or CAR-T Therapy Eligible Diffuse B-Cell Lymphoma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

November 4, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Diffuse Large B-Cell Lymphoma (DLBCL)
Interventions
DRUG

Glofitamab

Participants will receive intravenous (IV) glofitamab for up to 3 cycles.

DRUG

Obinutuzumab

Participants will receive IV obinutuzumab on Cycle 1 Day 1.

DRUG

Tocilizumab

Participants will receive IV tocilizumab as necessary to manage cytokine release syndrome (CRS) events.

DRUG

Rituximab

Participants will receive up to 2 doses of IV rituximab.

DRUG

Ifosfamide

Participants will receive IV ifosfamide for up to 3 cycles.

DRUG

Carboplatin

Participants will receive IV carboplatin for up to 3 cycles.

DRUG

Etoposide

Participants will receive IV etoposide for up to 3 cycles.

Trial Locations (9)

10016

New York University Langone Medical Center, New York

33028

Memorial Cancer Institute at Memorial West, Pembroke Pines

44195

Cleveland Clinic Foundation, Cleveland

53226

Medical College of Wisconsin, Milwaukee

60637

The University of Chicago, Chicago

70112

Tulane Medical Center, New Orleans

77030

MD Anderson Cancer Center, Houston

92868

Chao Family Comprehensive Cancer Center UCI, Orange

01655

UMASS Memorial Medical Center, Worcester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY