NCT05363514View on ClinicalTrials.gov

Low Dose Naltrexone Use in Patients With POTS

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

January 31, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

December 31, 2028

Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
DRUG

Low Dose Naltrexone

Participant takes Low Dose Naltrexone 4.5mg PO OD for 120 days. Participant will complete a a 4 week titration to target dose of 4.5mg. Week 1-2: 1.5mg PO OD. Week 3-4: 3.0mg PO OD. Week 5-16: 4.5mg PO OD. Participant will be provided with masked capsules in blister packs.

DRUG

Microcrystalline cellulose

Participant takes microcrystalline cellulose 4.5mg PO OD for 120 days. Participant will complete a a 4 week titration to target dose of 4.5mg. Week 1-2: 1.5mg PO OD. Week 3-4: 3.0mg PO OD. Week 5-16: 4.5mg PO OD. Participant will be provided with masked capsules in blister packs.

All Listed Sponsors
lead

University of Calgary

OTHER