First-Line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects With Extensive Stage Small Cell Lung Cancer (ES-SCLC)

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

184

Participants

Timeline

Start Date

August 24, 2022

Primary Completion Date

August 28, 2028

Study Completion Date

August 28, 2028

Conditions
Extensive Stage Small Cell Lung Cancer
Interventions
DRUG

Tarlatamab

Tarlatamab will be administered as an intravenous (IV) infusion.

DRUG

Carboplatin

Carboplatin will be administered as an intravenous (IV) infusion.

DRUG

Etoposide

Etoposide will be administered as an intravenous (IV) infusion.

DRUG

Atezolizumab

Atezolizumab will be administered as an intravenous (IV) infusion.

DRUG

Durvalumab

Durvalumab will be administered as an intravenous (IV) infusion.

Trial Locations (44)

2050

Chris OBrien Lifehouse, Camperdown

2100

Rigshospitalet, Copenhagen

2650

Universitair Ziekenhuis Antwerpen, Edegem

3010

Inselspital Bern, Bern

3500

Jessa Ziekenhuis - Campus Virga Jesse, Hasselt

4031

Universitaetsspital Basel, Basel

8800

AZ Delta Campus Rumbeke, Roeselare

9000

Algemeen Ziekenhuis Maria Middelares, Ghent

10002

National Taiwan University Hospital, Taipei

10016

New York University Grossman School of Medicine and New York University Langone Hospitals, New York

11217

Taipei Veterans General Hospital, Taipei

19713

Christiana Care Health Services, Newark

20900

Fondazione IRCCS San Gerardo dei Tintori, Monza (MB)

26506

West Virginia University Health Sciences Center, Morgantown

27599

The University of North Carolina at Chapel Hill, Chapel Hill

28041

Hospital Universitario 12 de Octubre, Madrid

44800

Centre Hospitalier Universitaire de Nantes, Hôpital Nord Laënnec, Saint-Herblain

45147

Universitaetsklinikum Essen, Essen

48202

Henry Ford Health System, Detroit

57105

Avera Cancer Institute, Sioux Falls

69373

Centre Leon Berard, Lyon

70403

National Cheng Kung University Hospital, Tainan City

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

88100

Azienda Ospedaliera Universitaria Renato Dulbecco, Catanzaro

90033

University of Southern California, Norris Comprehensive Cancer Center, Los Angeles

94805

Gustave Roussy, Villejuif

98104

Swedish Cancer Institute Medical Oncology, Seattle

3109601

Rambam Medical Center, Haifa

4941492

Rabin Medical Center, Petah Tikva

5265601

Sheba Medical Center, Ramat Gan

9112001

Hadassah Ein-Kerem Medical Center, Jerusalem

08901

Rutgers Cancer Institute of New Jersey, New Brunswick

M5G 2M9

Princess Margaret Cancer Centre, Toronto

G1R 2J6

CHU de Quebec Hopital de l Enfant Jesus, Québec

01307

Universitaetsklinikum Dresden, Dresden

00144

Istituto Nazionale Tumori Regina Elena, Rome

277-8577

National Cancer Center Hospital East, Kashiwa-shi

135-8550

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08916

Institut Catala d Oncologia Badalona Hospital Universitari Germans Trias i Pujol, Badalona

08035

Hospital Universitari Vall d Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY