400
Participants
Start Date
May 1, 2022
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2027
Chronic hyperglycemia
For each follow-up, the glycated albumin(GA) reflecting glycemic control of the past 2-3 weeks, the glycated hemoglobin(HbA1c) reflecting glycemic control of the past 2-3 months, and the advanced glycation end products(AGEs) will be measured.
Residual islet function
For each follow-up, fasting and stimulated C-peptide levels will be measured.
Genetic variation
Genetic variations of interest will be detected with the blood sample collected at baseline.
Dietary constitutes
For each follow-up, the dietary constitutes for the past 3 days will be recorded.
Microbiome composition and function
For each follow-up, the fecal and oral samples will be collected for measurement.
Metabolome composition
For each follow-up, the serum and urine samples will be collected for measurement.
Composition of peripheral blood immune cells
For each follow-up, the peripheral blood mononuclear cells will be collected for measurement.
RECRUITING
Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha
Second Xiangya Hospital of Central South University
OTHER