Clinical Characteristics of People With Long-term Type 1 Diabetes

RecruitingOBSERVATIONAL
Enrollment

400

Participants

Timeline

Start Date

May 1, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2027

Conditions
Type 1 Diabetes
Interventions
BIOLOGICAL

Chronic hyperglycemia

For each follow-up, the glycated albumin(GA) reflecting glycemic control of the past 2-3 weeks, the glycated hemoglobin(HbA1c) reflecting glycemic control of the past 2-3 months, and the advanced glycation end products(AGEs) will be measured.

BIOLOGICAL

Residual islet function

For each follow-up, fasting and stimulated C-peptide levels will be measured.

GENETIC

Genetic variation

Genetic variations of interest will be detected with the blood sample collected at baseline.

DIETARY_SUPPLEMENT

Dietary constitutes

For each follow-up, the dietary constitutes for the past 3 days will be recorded.

GENETIC

Microbiome composition and function

For each follow-up, the fecal and oral samples will be collected for measurement.

BIOLOGICAL

Metabolome composition

For each follow-up, the serum and urine samples will be collected for measurement.

BIOLOGICAL

Composition of peripheral blood immune cells

For each follow-up, the peripheral blood mononuclear cells will be collected for measurement.

Trial Locations (1)

410001

RECRUITING

Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha

All Listed Sponsors
lead

Second Xiangya Hospital of Central South University

OTHER