ACHIEVE - Efficacy and Effectiveness of Adoptive Cellular tHerapy wIth Ex-Vivo Expanded Allogeneic γδ T-lymphocytes (TCB008) for Patients With Refractory or Relapsed Acute Myeloid Leukaemia (AML)

PHASE2TerminatedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

August 15, 2022

Primary Completion Date

July 30, 2025

Study Completion Date

July 30, 2025

Conditions
Acute Myeloid LeukemiaMyelodysplastic Syndromes
Interventions
DRUG

TCB008

TCB008 is derived from the peripheral blood mononuclear cells (PBMCs) of unrelated, healthy donors and consists of expanded cluster designation (CD)3+ T cells expressing the γ chain variable region 9 δ-chain variable region 2 (Vγ9Vδ2) T cell receptor (TCR); it is infused into patients to boost their immune system. It is currently developed for treatment of cancers and infectious diseases.

Trial Locations (6)

BS2 8ED

Bristol and Weston NHS foundation trust, Bristol

CF14 4HH

Cardiff and Vale University LHB, Cardiff

G51 4TF

Queen Elizabeth University Hospital, Glasgow

SE1 7EH

Guys&St Thomas NHS foundation Trust, London

SE5 9RS

Kings College Hospital, London

SW3 6JJ

Royal Marsden Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

TC Biopharm

INDUSTRY

NCT05358808 - ACHIEVE - Efficacy and Effectiveness of Adoptive Cellular tHerapy wIth Ex-Vivo Expanded Allogeneic γδ T-lymphocytes (TCB008) for Patients With Refractory or Relapsed Acute Myeloid Leukaemia (AML) | Biotech Hunter | Biotech Hunter