A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

252

Participants

Timeline

Start Date

April 25, 2022

Primary Completion Date

February 15, 2025

Study Completion Date

August 15, 2025

Conditions
Huntington Disease
Interventions
DRUG

PTC518

PTC518 will be administered per dose and schedule specified in the arm.

DRUG

Placebo

Placebo matching to PTC518 will be administered per schedule specified in the arm.

Trial Locations (28)

2145

Westmead Hospital, Sydney

3168

Monash Health, Clayton

6020

Medical University Innsbruck, Innsbruck

8011

University of Otago, New Zealand Brain Research Institute, Christchurch

8025

Hospital de la Santa Creu I Sant Pau, Barcelona

10117

Charite University Medicine Berlin, Berlin

13385

Hôpital Universitaire de Marseille Hôpital de la Timone, Marseille

20133

IRCCS Carlo Besta Neurological Institutte, Milan

28034

Hospital Ramón y Cajal, Madrid

37212

Vanderbilt University Medical Center, Nashville

40139

Irccs Istituto Delle Scienze Neurologiche Di Bologna Uoc Clinica Neurologica, Bologna

44791

Ruhr-Univ. Bochum St. Joseph-Hospital, Bochum

48149

George-Huntington-Institut, Münster

48903

Hospital Universitario Cruces, Barakaldo

49100

Centre Hospitalier Universitaire d'Angers, Angers

71013

IRCCS Casa Sollievo della Sofferenza Research Hospital, San Giovanni Rotondo

75013

Brain and Spine Institute Paris, Paris

77030

The University of Texas Health Science Center at Houston; McGovern Medical School, Houston

89081

Ulm University, UKU, Dep. of Neurology, Ulm

90550

Hospital Universitario Burgos, Burgos

92037

University of California, San Diego, La Jolla

98195

University of Washington Department of Neurology, Seattle

K1Y 4E9

The Ottawa Hospital, Parkinson's and Movement Disorders Clinic, Ottawa

2333 ZA

Leiden University Medical Center, Leiden

B15 2FG

The Barbery National Centre for Mental Health, Birmingham

CF10 3AX

Cardiff University Schools of Medicine and Biosciences, Cardiff

WC1N 3BG

UCL Queen Square Institute of Neurology National Hospital for Neurology and Neurosurgery, London

M13 9WL

Manchester University NHS Foundation Trust, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

PTC Therapeutics

INDUSTRY

NCT05358717 - A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) | Biotech Hunter | Biotech Hunter