PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally Advanced ESCC (NEOCRTEC2101)

Sintilimab 200mg, IV (in the vein) on day 1 and day 22

External radiation with a total dose of 40.0 or 45.0 Gy is given in 20 fractions,5 fractions a week.

50mg/m2, IV (in the vein) on day 1,day 8,day 15 and day 22

25mg/m2,IV DRIP on day 1,day 8,day 15 and day 22

McKeown esophagectomy, Ivor Lewis esophagectomy or minimally invasive esophagectomy will be performed 6-8 weeks after chemoradiotherapy. Two-field lymphadenectomy with total mediastinal lymph node dissection is performed during surgery.