Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents

PHASE2RecruitingINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

May 4, 2022

Primary Completion Date

August 30, 2025

Study Completion Date

December 15, 2025

Conditions
Asthma
Interventions
DRUG

Dupilumab

Dupilumab is a recombinant DNA-derived humanized IgG4ĸ monoclonal antibody that selectively binds to anti IL-4R monoclonal antibody (mAb).

DRUG

Placebo

The composition of the placebo for dupilumab is the same as the active study drug without the dupilumab.

Trial Locations (8)

10029

RECRUITING

Icahn School of Medicine at Mount Sinai: Division of Clinical Immunology, Immunology Institute, New York

10032

RECRUITING

Columbia University Medical Center: Division of Pediatric Pulmonology, New York

20010

RECRUITING

Children's National Medical Center: Children's Research Institute, Washington D.C.

45229

RECRUITING

Cincinnati Children's Hospital Medical Center: Asthma Center, Cincinnati

60611

RECRUITING

Ann & Robert H. Lurie Children's Hospital of Chicago: Division of Allergy and Immunology, Chicago

63110

RECRUITING

Washington University at St. Louis, St Louis

80045

RECRUITING

Children's Hospital Colorado: Allergy Program, Aurora

02215

ACTIVE_NOT_RECRUITING

Boston Children's Hospital: Department of Immunology, Boston

All Listed Sponsors
collaborator

Childhood Asthma in Urban Settings (CAUSE)

UNKNOWN

collaborator

Regeneron Pharmaceuticals

INDUSTRY

collaborator

Rho Federal Systems Division, Inc.

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT05347771 - Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents | Biotech Hunter | Biotech Hunter