A Study of TQB2450 Injection Plus Chemotherapy Followed by TQB2450 Plus Anlotinib Versus Tislelizumab Plus Chemotherapy Followed by Tislelizumab in the Treatment of First-line Non-squamous Non-small Cell Lung Cancer(NSCLC).

PHASE3UnknownINTERVENTIONAL
Enrollment

390

Participants

Timeline

Start Date

January 25, 2022

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2023

Conditions
Advanced Non-squamous Non-small Cell Lung Cancer
Interventions
DRUG

TQB2450 injection, Tilelizumab injection, Anlotinib hydrochloride capsule, Pemetrexed disodium injection, Carboplatin injection

PD-L1(programmed cell death-Ligand 1) may be expressed on tumor cells and/or tumor-infiltrating immune cells, which can inhibit the anti-tumor immune response in the tumor microenvironment. On T cells and antigen-presenting cells, PD-L1 binding to PD-1 (programmed cell death-1) and B7.1 receptors inhibits cytotoxic T cell activation, T cell proliferation, and cytokine production.

Trial Locations (1)

100021

RECRUITING

Chinese Academy of Medical Sciences Cancer Hospital, Beijing

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY