Clinical Study of DTX301 AAV-Mediated Gene Transfer for Ornithine Transcarbamylase (OTC) Deficiency

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

October 18, 2022

Primary Completion Date

February 19, 2025

Study Completion Date

March 31, 2031

Conditions
OTC Deficiency
Interventions
GENETIC

DTX301

non-replicating, self-complementary recombinant adeno-associated virus serotype 8 (AAV8) vector

OTHER

Placebo

normal saline infusion

DRUG

Oral Corticosteroids

Participants who receive DTX301 solution will receive oral corticosteroids.

DRUG

Placebo for oral corticosteroids

Participants who receive Placebo will receive placebo corticosteroids to maintain the study blind

DRUG

Sodium Acetate

A tracer for the Ureagenesis Rate Test (URT)

Trial Locations (16)

3015

Erasmus Universitair Medisch Centrum Rotterrdam, Rotterdam

44106

University Hospitals Cleveland Medical Center, Cleveland

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

69120

Universitatsklinikum Heidelberg, Heidelberg

69500

Hopital Femme Mere Enfant, Bron

75015

Necker-Enfants Maladas Hospital, Paris

80045

University of Colorado, Aurora

90095

University of California, Los Angeles

C1199

Hospital Italiano de Buenos Aires, Buenos Aires

X5004

Clinica Universitaria Reina Fabiola, Córdoba

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

M5G 1X8

The Hospital for Sick Children, Toronto

860-8556

Kumamoto University Hospital, Kumamoto

470-1192

Fujita Health University Hospital, Toyoake

4200-319

Centro Hospitalar Universitario de Sao Joao, Porto

08035

Fundacio Hospital Universitari Vall D'Hebron-Institute de Recerca, Barcelona

All Listed Sponsors
lead

Ultragenyx Pharmaceutical Inc

INDUSTRY