All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

PHASE2RecruitingINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

November 16, 2022

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2027

Conditions
GliomaIDH MutationAstrocytomaOligodendroglioma
Interventions
DRUG

Retifanlimab

Administered 500mg IV on day 1 of every 28-day cycle, continued until disease progression, unacceptable toxicity, or 2 years from the first dose of study medication, whichever occurs first.

DRUG

All-trans retinoic acid

All-trans retinoic acid (ATRA) 45mg/m2 orally in two equally divided doses on days 1-14 of each 28-day cycle, continued until disease progression, unacceptable toxicity, or 2 years from the first dose of study medication, whichever occurs first.

Trial Locations (1)

19104

RECRUITING

University of Pennsylvania, Philadelphia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Incyte Corporation

INDUSTRY

collaborator

University of Pennsylvania

OTHER

lead

Stephen Bagley, MD, MSCE

OTHER