Retinal Blood Flow and Autoregulation

PHASE4RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

May 23, 2022

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
Glaucoma
Interventions
DIAGNOSTIC_TEST

Indocyanine Green Angiography

Erythrocyte Mediated Angiography with indocyanine green as well as conventional indocyanine green angiography will be conducted to determine retinal blood flow

BIOLOGICAL

Isocapnic Oxygen

Investigators will evaluate retinal blood flow (RBF) in response to oxygen supplementation at a constant level of carbon dioxide (isocapnic hyperoxia) to isolate the vascular autoregulatory response to oxygen.

DIAGNOSTIC_TEST

Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO)

Investigators will image subjects with OCT as well as AO technology to determine retinal ganglion cell density, vessel density, and vessel flowrates

Trial Locations (4)

20903

RECRUITING

Food and Drug Administration (FDA), Silver Spring

21201

RECRUITING

University of Maryland Faculty Physicians, Inc, Baltimore

RECRUITING

University of Maryland Medical Center, Baltimore

RECRUITING

University of Maryland, Baltimore, Baltimore

All Listed Sponsors
lead

University of Maryland, Baltimore

OTHER