Efficacy and Safety of Anti-PD-1/PD-L1 Treatment +/- UV1 Vaccination in Patients With Non-small Cell Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

August 12, 2022

Primary Completion Date

July 1, 2025

Study Completion Date

July 1, 2027

Conditions
OncologyNSCLC Stage IVNSCLC, Stage III
Interventions
BIOLOGICAL

UV1

UV1 vaccine

DRUG

Sagramostim

for stimulation of local dendritic cell population to take up the vaccine and to mature into professional APCs

DRUG

Anti-PD-1/PD-L1 treatment

either pembrolizumab, atezolizumab or cemiplimab

Trial Locations (1)

3004

RECRUITING

Vestre Viken Health Trust, Drammen

All Listed Sponsors
collaborator

University Hospital, Akershus

OTHER

collaborator

Oslo University Hospital

OTHER

collaborator

Haukeland University Hospital

OTHER

collaborator

Helse Stavanger HF

OTHER_GOV

collaborator

Helse Fonna

OTHER

collaborator

Helse Nord-Trøndelag HF

OTHER

collaborator

St. Olavs Hospital

OTHER

collaborator

Alesund Hospital

OTHER

collaborator

Helse Forde

OTHER

collaborator

University Hospital of North Norway

OTHER

lead

Vestre Viken Hospital Trust

OTHER