A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

July 27, 2022

Primary Completion Date

November 13, 2025

Study Completion Date

November 13, 2025

Conditions
Esophageal Squamous Cell Carcinoma (ESCC)
Interventions
BIOLOGICAL

Pembrolizumab

200 mg administered via intravenous (IV) infusion every 3 weeks (Q3W)

BIOLOGICAL

Coformulation favezelimab/pembrolizumab

800 mg favezelimab + 200 mg pembrolizumab administered via IV infusion on day 1 and then Q3W

BIOLOGICAL

MK-4830

800 mg administered via IV infusion Q3W

DRUG

Lenvatinib

20 mg administered via oral capsules each day

DRUG

Irinotecan

180 mg/m\^2 administered via IV infusion on day 1 of every 14-day cycle.

DRUG

Paclitaxel

80-100 mg/m\^2 administered via IV infusion on Days 1, 8 and 15 of every 28 day cycle

Trial Locations (46)

112

Taipei Veterans General Hospital ( Site 2005), Taipei

333

Chang Gung Medical Foundation-Linkou Branch ( Site 2006), Taoyuan District

407

Taichung Veterans General Hospital-Radiation Oncology ( Site 2008), Taichung

704

National Cheng Kung University Hospital ( Site 2001), Tainan City

1211

Hôpitaux Universitaires de Genève (HUG) ( Site 2702), Geneva

7000

Kantonsspital Graubünden-Medizin ( Site 2700), Chur

10002

National Taiwan University Hospital ( Site 2000), Taipei

10330

Chulalongkorn University ( Site 2104), Bangkok

10700

Faculty of Medicine Siriraj Hospital ( Site 2102), Bangkok

13353

Charité Campus Virchow-Klinikum-Klinik Hämatologie Onkologie Tumorimmunologie ( Site 2804), Berlin

20132

Ospedale San Raffaele-Oncologia Medica ( Site 1206), Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1200), Milan

20141

Istituto Europeo di Oncologia IRCCS-Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative (, Milan

25070

Atatürk Üniversitesi-onkoloji ( Site 1416), Erzurum

29200

Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan ( Site 1104), Brest

34662

Acibadem Altunizade Hospital-Oncology ( Site 1407), Üsküdar / İstanbul

34722

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1403), Istanbul

35128

Istituto Oncologico Veneto IRCCS ( Site 1205), Padua

40225

Universitaetsklinikum Duesseldorf ( Site 2802), Düsseldorf

59037

Hopital Claude Huriez - CHU de Lille ( Site 1100), Lille

60488

Institut für Klinisch Onkologische Forschung-Klink für Onkologie und Hämatologie ( Site 2801), Frankfurt am Main

75013

Pitie Salpetriere University Hospital ( Site 1102), Paris

83301

Chang Gung Memorial Hospital at Kaohsiung ( Site 2003), Kaohsiung Niao Sung Dist

90110

Songklanagarind hospital ( Site 2105), Hat Yai

119074

National University Hospital ( Site 1800), Singapore

404332

China Medical University Hospital ( Site 2007), Taichung

7500921

FALP-UIDO ( Site 2400), Santiago

7591047

Clínica las Condes ( Site 2403), Santiago

59062-000

Liga Norte Riograndense Contra o Câncer ( Site 2303), Natal

91350-200

Hospital Nossa Senhora da Conceição ( Site 2301), Porto Alegre

01246-000

ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 2300), São Paulo

01307

Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 2806), Dresden

464-8681

Aichi Cancer Center Hospital ( Site 1702), Nagoya

277-8577

National Cancer Center Hospital East ( Site 1701), Kashiwa

362-0806

Saitama Prefectural Cancer Center ( Site 1703), Ina-machi

411-8777

Shizuoka Cancer Center ( Site 1704), Nagaizumi-cho,Sunto-gun

104-0045

National Cancer Center Hospital ( Site 1700), Chuo-ku

0310

Oslo universitetssykehus, Radiumhospitalet ( Site 2501), Oslo

05505

Asan Medical Center-Department of Oncology ( Site 1901), Seoul

06351

Samsung Medical Center-Division of Hematology/Oncology ( Site 1900), Seoul

009035575

I.E.U. Medical Point Hastanesi-Oncology ( Site 1406), Izmir, Karsiyaka

01140

Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 1417), Adana

06230

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1402), Ankara

06520

Memorial Ankara Hastanesi-Medical Oncology ( Site 1408), Ankara

06800

Ankara City Hospital-Medical Oncology ( Site 1405), Ankara

07059

Akdeniz Universitesi Hastanesi-Medical Oncology ( Site 1410), Antalya

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY