6,500
Participants
Start Date
July 11, 2023
Primary Completion Date
September 30, 2026
Study Completion Date
September 30, 2026
patient-centered TB preventive therapy
The intervention phase includes i) enrolling participants who have had TB disease excluded and allowing participant selection of a preferred TPT regimen, and ii) randomizing participants to one of two participant adherence support modalities.
TB preventive therapy adherence support
As part of this study, enhanced adherence support will be provided via bi-directional messaging and/or via clinic phone calls. All participants randomized to enhanced adherence support will receive a weekly text reminder beginning seven days after the initiation. Each message will ask participants if they would like to be contacted to discuss any questions and will prompt participants to ask questions by text if more convenient or preferable. All text-based questions from participants will be answered by a trained nurse with back up from a physician.
RECRUITING
Baylor College of Medicine Children's Foundation, Mbabane
RECRUITING
Baylor College of Medicine Children's Foundation, Maseru
RECRUITING
Baylor College of Medicine Children's Foundation, Lilongwe
RECRUITING
Baylor College of Medicine Children's Foundation, Mbeya
RECRUITING
Baylor College of Medicine Children's Foundation, Kampala
Centers for Disease Control and Prevention
FED
London School of Hygiene and Tropical Medicine
OTHER
University of Ottawa
OTHER
University of Stellenbosch
OTHER
Baylor College of Medicine
OTHER