Closing -TB GAPs - for People Living With HIV: TB Guidance for Adaptable Patient-Centered Service

NARecruitingINTERVENTIONAL
Enrollment

6,500

Participants

Timeline

Start Date

July 11, 2023

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
TuberculosisHIV CoinfectionTuberculosis Infection
Interventions
OTHER

patient-centered TB preventive therapy

The intervention phase includes i) enrolling participants who have had TB disease excluded and allowing participant selection of a preferred TPT regimen, and ii) randomizing participants to one of two participant adherence support modalities.

OTHER

TB preventive therapy adherence support

As part of this study, enhanced adherence support will be provided via bi-directional messaging and/or via clinic phone calls. All participants randomized to enhanced adherence support will receive a weekly text reminder beginning seven days after the initiation. Each message will ask participants if they would like to be contacted to discuss any questions and will prompt participants to ask questions by text if more convenient or preferable. All text-based questions from participants will be answered by a trained nurse with back up from a physician.

Trial Locations (5)

Unknown

RECRUITING

Baylor College of Medicine Children's Foundation, Mbabane

RECRUITING

Baylor College of Medicine Children's Foundation, Maseru

RECRUITING

Baylor College of Medicine Children's Foundation, Lilongwe

RECRUITING

Baylor College of Medicine Children's Foundation, Mbeya

RECRUITING

Baylor College of Medicine Children's Foundation, Kampala

All Listed Sponsors
collaborator

Centers for Disease Control and Prevention

FED

collaborator

London School of Hygiene and Tropical Medicine

OTHER

collaborator

University of Ottawa

OTHER

collaborator

University of Stellenbosch

OTHER

lead

Baylor College of Medicine

OTHER