PD-1 Blockade and Bevacizumab Replace Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

April 30, 2022

Primary Completion Date

April 30, 2023

Study Completion Date

December 30, 2025

Conditions
Nasopharyngeal Carcinoma
Interventions
DRUG

Bevacizumab+Toripalimab+gemcitabine, adjuvant with Bevacizumab and Toripalimab

"Induction therapy:~Toripalimab (240mg iv drip)+Bevacizumab (7.5mg/kg iv drip)+gemcitabine (1,000 mg/m2), every 3 weeks for 3 cycles before radiotherapy.~Concurrent therapy:~Toripalimab (240mg iv drip)+Bevacizumab (7.5mg/kg iv drip), every 3 weeks for 2 cycles during radiotherapy.~Adjuvant therapy:~Toripalimab (240mg iv drip)+Bevacizumab (7.5mg/kg iv drip), every 3 weeks for 1 year after radiotherapy.~Radiation:~Intensity-modulated radiotherapy."

DRUG

Bevacizumab+Toripalimab+gemcitabine, adjuvant with Toripalimab

"Induction therapy:~Toripalimab (240mg iv drip)+Bevacizumab (7.5mg/kg iv drip)+gemcitabine (1,000 mg/m2), every 3 weeks for 3 cycles before radiotherapy.~Concurrent therapy:~Toripalimab (240mg iv drip)+Bevacizumab (7.5mg/kg iv drip), every 3 weeks for 2 cycles during radiotherapy.~Adjuvant therapy:~Toripalimab (240mg iv drip), every 3 weeks for 1 year after radiotherapy.~Radiation:~Intensity-modulated radiotherapy."

Trial Locations (1)

510060

Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
collaborator

The First Affiliated Hospital of Nanchang University

OTHER

lead

Sun Yat-sen University

OTHER

NCT05341193 - PD-1 Blockade and Bevacizumab Replace Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma | Biotech Hunter | Biotech Hunter