Chemoradiotherapy Plus Anti-PD1 in Recurrent NPC: A Multicenter, Open-label, Randomised, Controlled, Phase III Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

212

Participants

Timeline

Start Date

April 1, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2027

Conditions
Nasopharyngeal Carcinoma
Interventions
DRUG

Toripalimab

240mg, D1, every 3 weeks per cycle, three cycles with chemotherapy and eight cycles after IMRT

DRUG

Chemotherapy

Gemcitabine: 1.0g/m2, D1 and D8, Cisplatin 80mg/m2, D1, every 3 weeks per cycle, total three cycles

RADIATION

Intensity modulated radiotherapy

total 60-66Gy, 1.8-2.0Gy/f/day

Trial Locations (12)

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

Unknown

RECRUITING

Peking University Third Hospital, Beijing

NOT_YET_RECRUITING

Sichuan Cancer Hospital, Chengdu

NOT_YET_RECRUITING

Fujian Province Cancer Hospital, Fuzhou

NOT_YET_RECRUITING

Guizhou Cancer Hospital, Guiyang

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

RECRUITING

Jiangxi Cancer Hospital, Nanchang

RECRUITING

The First Affiliated Hospital of Guangxi Medical University, Nanning

NOT_YET_RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

RECRUITING

Zhongnan Hospital of Wuhan University, Wuhan

RECRUITING

Xijing Hospital, Xi'an

NOT_YET_RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

All Listed Sponsors
lead

Sun Yat-sen University

OTHER