PD-1 Inhibitor Plus GP as Neoadjuvant Therapy for Locoregionally Advanced Nasopharyngeal Carcinoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

146

Participants

Timeline

Start Date

July 15, 2022

Primary Completion Date

March 29, 2026

Study Completion Date

March 29, 2026

Conditions
Nasopharyngeal CarcinomaNeoadjuvant TherapyPD-1 Inhibitor
Interventions
DRUG

PD-1 inhibitor+GP

PD-1 inhibitor (200-240mg), gemcitabine (1000mg/m2 on day 1,8) and cisplatin (80mg/m2 on day 1) every three weeks for three cycles as neoadjuvant therapy, then followed by IMRT and cisplatin (100mg/m2, d1, 22, 43 of RT) during concurrent chemoradiotherapy.

DRUG

GP

Gemcitabine (1000mg/m2 on day 1,8) and cisplatin (80mg/m2 on day 1) every three weeks for three cycles as neoadjuvant therapy, then followed by IMRT and cisplatin (100mg/m2, d1, 22, 43 of RT) during concurrent chemoradiotherapy.

Trial Locations (1)

530021

The First Affiliated Hospital of Guangxi Medical University, Nanning

All Listed Sponsors
collaborator

Hainan People's Hospital

OTHER

collaborator

Wuzhou Red Cross Hospital

OTHER

collaborator

First People's Hospital of Yulin

OTHER

collaborator

Fourth Affiliated Hospital of Guangxi Medical University

OTHER

collaborator

Guigang People's Hospital

OTHER

collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

Yunnan Cancer Hospital

OTHER

collaborator

LiuZhou People's Hospital

OTHER

collaborator

Affiliated Hospital of North Sichuan Medical College

OTHER

lead

Guangxi Medical University

OTHER