NCT05331144View on ClinicalTrials.gov

Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)

PHASE2RecruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

October 25, 2022

Primary Completion Date

June 1, 2027

Study Completion Date

December 31, 2027

Conditions
Cognitively Normal Older AdultsHypertensionSubjective Cognitive DeclineFamily History of Dementia
Interventions
DRUG

Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine)

Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine) will be used to treat high blood pressure. Additional antihypertensive medications may be used if needed.

OTHER

PCP

Participants will follow their PCP's recommendations for BP control.

Trial Locations (1)

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

collaborator

Texas Health Resources

OTHER

collaborator

Michigan State University

OTHER

lead

Rong Zhang

OTHER