Modi-1 Moditope in Breast, Head and Neck, Ovarian, or Renal Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

April 7, 2022

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2027

Conditions
Triple Negative Breast CancerRenal Cell CancerHigh Grade Ovarian Serous AdenocarcinomaSquamous Cell Carcinoma of the Head and Neck
Interventions
BIOLOGICAL

Modi-1 Moditope

Modi-1 Moditope administered intradermally (i.d.) using the MicronJet600™ microneedle device (NanoPass).

BIOLOGICAL

Pembrolizumab

Pembrolizumab (exploratory cohorts) will be administered by intravenous infusion on Day 8, prior to tumour resection surgery at 6 weeks.

DEVICE

MicronJet600™ microneedle device (NanoPass)

Intradermal injection device

Trial Locations (16)

Unknown

ACTIVE_NOT_RECRUITING

Brighton and Sussex University Hospital, Brighton

RECRUITING

Velindre Cancer Centre, Cardiff

RECRUITING

Edinburgh Cancer Centre (NHS Lothian), Edinburgh

RECRUITING

Royal Surrey NHS Foundation, Guildford

ACTIVE_NOT_RECRUITING

Imperial College Healthcare NHS Trust, London

RECRUITING

Mount Vernon, London

RECRUITING

University College London Hospital NHS Foundation Trust, London

RECRUITING

Christie NHS Foundation Trust, Manchester

RECRUITING

Nottingham University Hospitals Cancer Centre, Nottingham

RECRUITING

Lancashire Teaching Hospitals NHS Foundation Trust, Preston

RECRUITING

Sheffield Teaching Hospital NHS Foundation Trust, Sheffield

NOT_YET_RECRUITING

The Royal Marsden NHS Foundation Trust, Sutton

RECRUITING

Belfast City Hospital, Belfast

RECRUITING

Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge

RECRUITING

Torbay and South Devon NHS Foundation Trust, Torquay

CH63 4JY

RECRUITING

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

All Listed Sponsors
lead

Scancell Ltd

INDUSTRY