15
Participants
Start Date
February 10, 2022
Primary Completion Date
February 10, 2024
Study Completion Date
February 10, 2027
fhB7H3.CAR-Ts
fhB7H3.CAR-Ts will be transhepatic arterial infused after lymphodepletion. Three dose levels will be evaluated: Dose Level 1 (1×10\^6/kg), dose Level 2 (3×10\^6/kg) and dose Level 3 (5×10\^6/kg). If dose limiting toxicities (DLTs) are observed in each doses, Dose Level -1 (0.5×10\^6/kg /infusion) will be evaluated.
Fludarabine
30 mg/m2 i.v. for 3 consecutive days (Day -5\~Day -3)
Cyclophosphamide
750 mg/m2 i.v. for once (Day -5)
RECRUITING
The Affiliated Hospital of Xuzhou Medical University, Xuzhou
Xuzhou Medical University
OTHER
IIT MediTech Co. Ltd
UNKNOWN
The Affiliated Hospital of Xuzhou Medical University
OTHER