Study Of B7H3 CAR-T Cells in Treating Advanced Liver Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

February 10, 2022

Primary Completion Date

February 10, 2024

Study Completion Date

February 10, 2027

Conditions
Hepatocellular Carcinoma
Interventions
BIOLOGICAL

fhB7H3.CAR-Ts

fhB7H3.CAR-Ts will be transhepatic arterial infused after lymphodepletion. Three dose levels will be evaluated: Dose Level 1 (1×10\^6/kg), dose Level 2 (3×10\^6/kg) and dose Level 3 (5×10\^6/kg). If dose limiting toxicities (DLTs) are observed in each doses, Dose Level -1 (0.5×10\^6/kg /infusion) will be evaluated.

DRUG

Fludarabine

30 mg/m2 i.v. for 3 consecutive days (Day -5\~Day -3)

DRUG

Cyclophosphamide

750 mg/m2 i.v. for once (Day -5)

Trial Locations (1)

221002

RECRUITING

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

All Listed Sponsors
collaborator

Xuzhou Medical University

OTHER

collaborator

IIT MediTech Co. Ltd

UNKNOWN

lead

The Affiliated Hospital of Xuzhou Medical University

OTHER