Study of 3D189 in Patients With Hematologic Malignancies

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

August 1, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

December 31, 2026

Conditions
Acute LeukemiaMultiple MyelomaNon-Hodgkin LymphomaHigher-risk Myelodysplastic Syndrome
Interventions
BIOLOGICAL

3D189

"3D189 (200 mcg per peptide x 4 WT1 peptides within the drug product; total weight: 800 mcg) is mixed (1:1 v/v) and emulsified with the adjuvant Montanide, which is then injected subcutaneously to the patient.~A maximum of 15 total injections of 3D189 will be administered as follows:~1. Initial immunization induction phase(the first series of 6 injections of 3D189): every 2 weeks (Weeks 0 - 10) followed by a 4-week period of no treatment.~2. Early immune booster phase(the second series of 6 injections of 3D189): every 4 weeks (between Weeks 14 and 34) followed by a 6-week period of no treatment.~3. Late immune booster phase(the third series of 3 injections of 3D189): every 6 weeks (between Weeks 40 and 52)."

Trial Locations (4)

330006

The First Affiliated Hospital Of Nanchang University, Nanchang

Unknown

Guangdong Provincial People's Hospital, Guangzhou

Shengjing Hospital of China Medical, Shengyang

Blood Disease Hospital , Chinese Academy of Medical Science, Tianjing

Sponsors

Lead Sponsor

All Listed Sponsors
lead

3D Medicines

INDUSTRY