Phase I/II Study of the Combination of Irinotecan and POF (POFI) and Tislelizumab

Oxaliplatin will be administered on day 1 of each cycle at 85mg/m2 once every 14 days.

Levo-Leucovorin will be administered on day 1 of each cycle at 200 mg/m2 once every 14 days.

5-fluorouracil will be administered at 2400 mg/m2 over 46-hour every 14 days.

Paclitaxel will be administered on day 1 of each cycle at 45mg/m2 at dose level 1; 67.5 mg/m2 at dose level 2 ; 90 mg/m2 at dose level 3; 112.5 mg/m2 at dose level 4 once every 14 days.

Irinotecan will be administered on day 1 of each cycle at 135 mg/m2 at dose level 1; 150 mg/m2 at dose level 2 once every 14 days.

Tislelizumab will be administered on day 1 of each cycle at 200mg once every 14 days.