Treateament of Newly Diagnosed Acute Monocytic Leukemia in Children

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

December 1, 2021

Primary Completion Date

March 30, 2026

Study Completion Date

March 30, 2026

Conditions
Leukemia, Monocytic, AcutePediatric AML
Interventions
DRUG

Cladribine

5mg/㎡/day d1-5 in 2 hours, before the use of Cytarabine

DRUG

G-CSF

5ug/kg/day d0-5,if Peripheral blood leukocytes\<20,000/ul

DRUG

Cytarabine

2g/㎡/day d1-5 in 4 hours, after the use of Cladribine

DRUG

Idarubicin

Idarubicin 10mg/m2/day or mitoxantrone 10mg/m2/day on day 1-3 in the induction therapy II

DRUG

Mitoxantrone

Idarubicin 10mg/m2/day or mitoxantrone 10mg/m2/day on day 1-3 in the induction therapy II

DRUG

Sorafenib

200mg/m2/day was taken orally until molecular biology remission for 2 years

Trial Locations (9)

Unknown

RECRUITING

Maternal and Child Health Hospital of Foshan, Foshan

RECRUITING

Guangzhou First People's Hospital, Guangzhou

RECRUITING

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

RECRUITING

Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou

RECRUITING

Zhujiang Hospital of Southern Medical University, Guangzhou

RECRUITING

Guangzhou First People's Hospital First Affiliated Hospital of Shantou University Medical College, Shantou

RECRUITING

Second Xiangya Hospital of Central South University, Changsha

RECRUITING

Jiangxi Province Children's Hospital Southern Medical University, China, Nanchang

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

All Listed Sponsors
collaborator

Third Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Maternal and Child Health Hospital of Foshan

OTHER

collaborator

The First Affiliated Hospital of Guangzhou Medical University

OTHER

collaborator

Second Xiangya Hospital of Central South University

OTHER

collaborator

Jiangxi Province Children's Hospital

OTHER

collaborator

Southern Medical University, China

OTHER

collaborator

The First Affiliated Hospital of Nanchang University

OTHER

collaborator

Guangzhou First People's Hospital

OTHER

collaborator

First Affiliated Hospital of Shantou University Medical College

OTHER

lead

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER