Evaluating the Effects of Liraglutide, Empagliflozin and Linagliptin on Mild Cognitive Impairment Remission in Patients With Type 2 Diabetes: a Multi-center, Randomized, Parallel Controlled Clinical Trial With an Extension Phase

NAActive, not recruitingINTERVENTIONAL
Enrollment

396

Participants

Timeline

Start Date

October 8, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Type 2 Diabetes MellitusMild Cognitive Impairment
Interventions
DRUG

Liraglutide

Liraglutide will be titrated from 0.6mg/day to 1.8mg/day during the first 2 weeks, if well tolerated. All patients will also continue on their existing dose and regimen of metformin throughout the study

DRUG

Empagliflozin

Empagliflozin will be initiated and maintained at 10mg/ day every morning until the completion of the study. All patients will also continue on their existing dose and regimen of metformin throughout the study.

DRUG

Linagliptin

Iinagliptin will be initiated at 5mg/ day every morning until the completion of the study. All patients will also continue on their existing dose and regimen of metformin throughout the study.

Trial Locations (5)

210000

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing

210008

Department of Endocrinology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing

211100

Department of Endocrinology, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing

213000

Department of Endocrinology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou

214000

Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi

All Listed Sponsors
collaborator

Nanjing First Hospital, Nanjing Medical University

OTHER

collaborator

The Affiliated Jiangning Hospital of Nanjing Medical University

OTHER

collaborator

Wuxi People's Hospital

OTHER

collaborator

Changzhou No.2 People's Hospital

OTHER

lead

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

OTHER