Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion)

PHASE3CompletedINTERVENTIONAL
Enrollment

807

Participants

Timeline

Start Date

May 5, 2022

Primary Completion Date

May 2, 2024

Study Completion Date

July 26, 2024

Conditions
Smoking Cessation
Interventions
DRUG

Cytisine

"Standard dosing of:~* days 1-3: one tablet (1.5mg) every two hours through the waking day (six tablets/day)~* days 4-12: one tablet every 2.5 hours (five tablets/day). Quit smoking date is day five.~* days 13-16: one tablet every three hours (four tablets/day)~* days 17-20: one tablet every 4-5 hours (three tablets/day)~* days 21-25: one tablet every six hours (two tablets/day)~Followed by a maintenance dose of cystine from day 26 to week 12 (one tablet every six hours: two tablets/day)"

DRUG

Nicotine delivered via an e-cigarette

Pod device delivering nicotine. Nicotine strength: 30mg/ml (3%). Flavour: Tobacco

COMBINATION_PRODUCT

Cytisine plus nicotine delivered via an e-cigarette

"Cytisine: Standard dosing of:~* days 1-3: one tablet (1.5mg) every two hours through the waking day (six tablets/day)~* days 4-12: one tablet every 2.5 hours (five tablets/day). Quit smoking date is day five.~* days 13-16: one tablet every three hours (four tablets/day)~* days 17-20: one tablet every 4-5 hours (three tablets/day)~* days 21-25: one tablet every six hours (two tablets/day)~Followed by a maintenance dose of cystine from day 26 to week 12 (one tablet every six hours: two tablets/day)~Nicotine e-cigarette: Pod device delivering nicotine. Nicotine strength: 30mg/ml (3%). Flavour: Tobacco"

Trial Locations (1)

1142

National Institute for Health Innovation, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland

All Listed Sponsors
lead

University of Auckland, New Zealand

OTHER