A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

May 17, 2022

Primary Completion Date

February 7, 2024

Study Completion Date

December 31, 2025

Conditions
Relapsed/Refractory Multiple Myeloma
Interventions
DRUG

ABBV-453

Oral; Tablet

DRUG

Dexamethasone

Oral Tablet

DRUG

Daratumumab

Subcutaneous Injection

DRUG

Lenalidomide

Oral Capsule

Trial Locations (21)

2170

Liverpool Hospital /ID# 244826, Liverpool

3065

St. Vincent's Private Hospital Melbourne /ID# 262631, Fitzroy

St Vincent's Hospital Melbourne /ID# 244827, Fitzroy Melbourne

3084

Austin Health and Ludwig Institute for Cancer Research /ID# 248311, Heidelberg

3121

Epworth Healthcare /ID# 248705, Richmond

20817

American Oncology Partners of Maryland /ID# 244858, Bethesda

27710

Duke Univ Med Ctr /ID# 242808, Durham

48109

University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 242754, Ann Arbor

70112

Tulane University School of Medicine /ID# 244854, New Orleans

91120

Hadassah Medical Center-Hebrew University /ID# 250484, Jerusalem

5265601

The Chaim Sheba Medical Center /ID# 250482, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 250483, Tel Aviv

94305-2200

Stanford University School of Med /ID# 242809, Stanford

33136-1002

Sylvester Comprehensive Cancer Center /ID# 243417, Miami

55905-0001

Mayo Clinic - Rochester /ID# 242844, Rochester

10065-6007

Memorial Sloan Kettering Cancer Center /ID# 243503, New York

28204-2990

Atrium Health Levine Cancer Institute /ID# 243420, Charlotte

27157-0001

Wake Forest Baptist Health /ID# 244252, Winston-Salem

19104-5502

University of Pennsylvania /ID# 242842, Philadelphia

37232-0021

Vanderbilt Ingram Cancer Center /ID# 242810, Nashville

E1 2ES

Barts Health NHS Trust /ID# 248972, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY