54
Participants
Start Date
December 26, 2021
Primary Completion Date
June 30, 2023
Study Completion Date
July 30, 2023
Autologous BMMNCs transplantation and educational intervention
"Biological/ Vaccine: Autologous bone marrow-derived mononuclear cell infusion (BM-MNCs) will be administrated at baseline, and the second infusion will be performed six months after the first administration. For each transplantation, the bone marrow will be harvested through an anterior iliac crest puncture under general anesthesia in the operating theatre. The volume collected depends on the patient's body weight based on our experience from a previous study as follows: 8 ml/kg for patients under 10 kg; \[80 ml + (body weight in kg - 10) x 7 ml\] for patients above 10 kg but no more than 250 ml in total.~Educational intervention: 6 months based on the Early Start Denver Model"
Educational intervention
Educational intervention: 6 months based on the Early Start Denver Model
Vinmec Research Institute of Stem Cell and Gene Technology, Hanoi
Vinmec Research Institute of Stem Cell and Gene Technology
OTHER