"Phase I / II Study on Infusion of Natural Killer Cells After Haploidentical Transplantation in Pediatric Patients"

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

November 30, 2020

Primary Completion Date

June 30, 2026

Study Completion Date

July 31, 2026

Conditions
High-risk Leukemias
Interventions
BIOLOGICAL

NK cells stimulated ex vivo with IL-15

When patient and donor are KIR-HLA match, the patient submits all HLA class I molecules, or in the absence of any, your donor does not have this molecule, or having it lacks the corresponding KIR receiver. For more information detailed information on the product under investigation, reference is made to the Dossier of the Research Product (IMPD): PEI 09-008

BIOLOGICAL

Alloreactive NK cells

When the patient lacks the HLA class I molecule and his donor has this molecule and also the donor NK cells have the KIR receptor that recognizes the absence of the corresponding HLA class I ligand

Trial Locations (10)

15706

Hospital Clínico Universitario de Santiago, Santiago de Compostela

28007

Hospital General Universitario Gregorio Marañón, Madrid

28009

Hospital Infantil Universitario Niño Jeús, Madrid

28046

Hospital Universitario La Paz, Madrid

29010

Hospital Regional Universitario de Málaga (Carlos de Haya), Málaga

30120

Hospital Clínico Universitario Virgen de la Arrixaca, Murcia

33011

Hospital Universitario Central de Asturias, Oviedo

41013

Hospital Universitario Virgen del Rocío, Seville

46026

Hospital Universitario La Fe, Valencia

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

All Listed Sponsors
lead

Instituto de Investigación Hospital Universitario La Paz

OTHER