64
Participants
Start Date
August 31, 2022
Primary Completion Date
August 31, 2027
Study Completion Date
August 31, 2027
Anti Thymocyte Globulin
2.5 mg/kg/day;2 doses on day -3 and day -2 for matched sibling donor transplantation;3 doses on day -4,-3 and day -2 for unrelated donor transplantation;4 doses on day -5,-4,-3 and day -2 for haploidentical donor transplantation
Fludarabine
30 mg/m2/day for 5 days
Cyclophosphamide injection
60 mg/kg/day for 2 days in cord blood stem cell transplantation
Topotecan
2mg/m2/day for 3 days in cord blood stem cell transplantation
Melphalan
70mg/m2/day,for peripheral stem cell transplantation or haploidentical bone marrow combined with peripheral stem cell transplantation;2 doses on day -3 and day -2 when conditioning regimen containing thiotepa;3 doses on day -4,-3 and day -2 when conditioning regimen not containing thiotepa;
Thiotepa
5 mg/kg/day for 2 days in peripheral stem cell transplantation or haploidentical bone marrow combined with peripheral stem cell transplantation
Busulfan
0.8mg/kg/dose;8 doses in cord blood stem cell transplantation;12 doses in peripheral stem cell transplantation or haploidentical bone marrow combined with peripheral stem cell transplantation when conditioning regimen containing thiotepa;16 doses in peripheral stem cell transplantation or haploidentical bone marrow combined with peripheral stem cell transplantation when conditioning regimen not containing thiotepa;
Cyclosporine
2.5\~4 mg/kg/dose every 12 hours orally;1.5\~2 mg /kg/dose every 12 hours intravenously; trough concentration maintained at 150\~250ng/ml
Tacrolimus
0.02\~0.03 mg/kg/day as continuous infusion or 12 hour divided doses
Mycophenolate Mofetil
15 mg/kg/dose every 12 hours
Methotrexate
15 mg/m2/dose on d+1 and 10 mg/m2/dose on d+3,d+6 in peripheral stem cell transplantation
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
OTHER