A Study of LVGN6051 Combined with Anlotinib in Patient with Soft Tissue Sarcoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

May 25, 2022

Primary Completion Date

March 19, 2025

Study Completion Date

October 19, 2025

Conditions
Soft Tissue Sarcoma
Interventions
COMBINATION_PRODUCT

LVGN6051 and Anlotinib

"LVGN6051: Route of administration is IV infusion, and the frequency of administration is once every 3 weeks(Q3W). One cycle is 3 weeks, and treatment can be up to 35 cycles if patients receive benefits. Anlotinib: Rout of administration is oral. The initial dose of anlotinib was 12 mg for subjects with body surface area ≥ 1.5m2 and 10 mg for subjects with body surface area \< 1.5m2. If the subjects in the combined treatment group were not tolerated, the dose of anlotinib was reduced to 10 mg for subjects with body surface area ≥ 1.5m2 and 8 mg for subjects with body surface area \< 1.5m2.~One cycle is 3 weeks, including oral for 2 weeks and withdrawal for 1 week."

Trial Locations (5)

200032

NOT_YET_RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

200233

NOT_YET_RECRUITING

Shanghai Sixth People's Hospital, Shanghai

310052

NOT_YET_RECRUITING

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

410031

RECRUITING

Hunan Cancer Hospital, Changsha

450008

NOT_YET_RECRUITING

Henan cancer hospital, Zhenzhou

All Listed Sponsors
lead

Lyvgen Biopharma Holdings Limited

INDUSTRY